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Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG
《化学科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 188-196 doi: 10.1007/s11705-014-1414-1
关键词: poly(ethylene glycol) monoacrylate phosphorylcholine polycarbonateurethane surface modification anti-platelet adhesion biomaterials
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.
关键词: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via
Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu
《医学前沿(英文)》 2019年 第13卷 第6期 页码 680-689 doi: 10.1007/s11684-018-0673-5
关键词: anti-
Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis
《医学前沿(英文)》 2022年 第16卷 第3期 页码 416-428 doi: 10.1007/s11684-021-0838-5
关键词: abivertinib Btk inhibitor platelet megakaryocyte megakaryopoiesis thrombopoiesis
Huan GU, Dacheng REN
《化学科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 20-33 doi: 10.1007/s11705-014-1412-3
关键词: surface engineering materials bacterial adhesion biofilm control review
Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 139-152 doi: 10.1007/s11684-017-0551-6
Current research on common musculoskeletal problems, including osteoarticular conditions, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients’ outcomes show partial improvements. Platelet-rich plasma can be customized to specific conditions by selecting the most appropriate formulation and timing for application or by combining platelet-rich plasma with synergistic or complementary treatments. To achieve this goal, researchers should identify and enhance the main mechanisms of healing. In this review, the interactions between platelet-rich plasma and healing mechanisms were addressed and research opportunities for customized treatment modalities were outlined. The development of combinational platelet-rich plasma treatments that can be used safely and effectively to manipulate healing mechanisms would be valuable and would provide insights into the processes involved in physiological healing and pathological failure.
关键词: regenerative medicine joint conditions muscle injuries platelet rich plasma tendinopathy healing mechanisms
Engineering platelet-mimicking drug delivery vehicles
Quanyin Hu, Hunter N. Bomba, Zhen Gu
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 624-632 doi: 10.1007/s11705-017-1614-6
关键词: drug delivery platelets nanomedicine bio-inspired biomimetic
Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie
《医学前沿(英文)》 2018年 第12卷 第6期 页码 667-677 doi: 10.1007/s11684-017-0583-y
关键词: platelet-mimicking delivery systems tumor-associated platelets cancer therapy EPR effect
On the applicability of different adhesion models in adhesive particulate flows
Guanqing LIU, Shuiqing LI, Qiang YAO,
《能源前沿(英文)》 2010年 第4卷 第2期 页码 280-286 doi: 10.1007/s11708-009-0062-5
关键词: adhesive contact van der Waals force adhesion model adhesion map DEM
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 447-451 doi: 10.1007/s11684-009-0082-x
关键词: cervical cancer lymphatic vessel density blood vessel density platelet-derived growth factor
Effect of interface adhesion factor on the bearing capacity of strip footing placed on cohesive soil
《结构与土木工程前沿(英文)》 2021年 第15卷 第6期 页码 1494-1503 doi: 10.1007/s11709-021-0768-y
关键词: bearing capacity soil-rock interface Hoek−Brown yield criterion plasticity limit analysis
Study on the cohesion and adhesion of hot-poured crack sealants
Meng GUO, Yiqiu TAN, Xuesong DU, Zhaofeng LV
《结构与土木工程前沿(英文)》 2017年 第11卷 第3期 页码 353-359 doi: 10.1007/s11709-017-0400-3
关键词: crack sealant concrete pavement cohesion adhesion moisture damage
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《医学前沿(英文)》 2016年 第10卷 第2期 页码 204-211 doi: 10.1007/s11684-016-0443-1
CD176 (Thomsen-Friedenreich antigen) is a tumor-associated carbohydrate epitope (glycotope) functionally involved in blood spread and liver metastasis of cancer cells by mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectively. CD176 could be a promising target for antitumor immunotherapy. We applied B lymphocytes obtained from mice immunized with CD176 antigen and constructed a phage display library. A positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened from this library. The CD176 scFv was expressed in Escherichia coli and purified. The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells. Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelial cells and hepatocytes. This CD176 scFv provides a basis for future development of recombinant CD176-specific antibodies that can be used in therapeutic application.
关键词: CD176 Thomsen-Friedenreich antigen scFv cancer therapy adhesion metastasis
《农业科学与工程前沿(英文)》 2023年 第10卷 第2期 页码 306-332 doi: 10.15302/J-FASE-2023488
● Using visual analysis to predict the trend of natural product pest resistance.
关键词: anti-pest activity crop protection insect pest natural product visual analysis
Xudong WANG,Miao ZHOU,Xiaorong MENG,Lei WANG,Danxi HUANG
《环境科学与工程前沿(英文)》 2016年 第10卷 第4期 doi: 10.1007/s11783-016-0855-9
关键词: PVDF membrane Membrane fouling Adhesion force Protein Interfacial free energy
标题 作者 时间 类型 操作
polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-plateletadhesion
Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG
期刊论文
Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two
null
期刊论文
Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via
Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu
期刊论文
Materials and surface engineering to control bacterial adhesion and biofilm formation: A review of recent
Huan GU, Dacheng REN
期刊论文
Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy
Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie
期刊论文
On the applicability of different adhesion models in adhesive particulate flows
Guanqing LIU, Shuiqing LI, Qiang YAO,
期刊论文
The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
期刊论文
Effect of interface adhesion factor on the bearing capacity of strip footing placed on cohesive soil
期刊论文
Study on the cohesion and adhesion of hot-poured crack sealants
Meng GUO, Yiqiu TAN, Xuesong DU, Zhaofeng LV
期刊论文
CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells
null
期刊论文
QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE
期刊论文